Description

4-Bromo-1H-Pyrazole-3-Carbonyl Chloride is a versatile and highly reactive chemical building block, primarily used as a key intermediate in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 4-bromo-1H-pyrazole moiety into target molecules, a crucial step in developing compounds with specific biological activities. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on novel active ingredients, kinase inhibitors, and other heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require the pyrazole scaffold.
• Chemical Research & Development: Serves as a fundamental building block in medicinal chemistry for creating diverse compound libraries and exploring new chemical spaces.
• Material Science: Potential use in the synthesis of advanced organic materials, such as ligands for catalysts or components for electronic materials.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in complex heterocycles.

Basic Information

Product Name	4-Bromo-1H-Pyrazole-3-Carbonyl Chloride
CAS No.	1006471-28-8
Molecular Formula	C4H2BrClN2O
Molecular Weight	209.43 g/mol
Synonyms	4-Bromo-1H-pyrazole-3-carbonyl chloride; 4-Bromo-1H-pyrazole-3-carboxylic acid chloride; 3-Carboxy-4-bromopyrazole chloride; 4-Bromopyrazole-3-carbonyl chloride; 1H-Pyrazole-3-carbonyl chloride, 4-bromo-; 4-Bromo-1H-pyrazole-3-carboxylic chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-1H-Pyrazole-3-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports applications requiring reliable and traceable raw materials for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.