Description

O6-(4-Aminomethylbenzyl)Cytosine is a specialized nucleoside analog derivative with a unique benzyl-aminomethyl modification at the O6 position. This structural feature makes it a valuable intermediate and research chemical in advanced pharmaceutical development, particularly for probing DNA repair mechanisms and designing targeted therapies. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, medicinal chemistry, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel chemotherapeutic agents and targeted cancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in studies of DNA alkyltransferase enzymes, such as MGMT (O6-methylguanine-DNA methyltransferase).
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new nucleoside-based therapeutics.
• Oncology Research: Investigated for its potential to sensitize tumor cells to alkylating chemotherapeutic agents by inhibiting DNA repair pathways.
• Academic Research: Utilized in university and institutional labs for fundamental studies in chemical biology and nucleotide chemistry.
• Process Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) in pre-clinical and clinical stages.

Basic Information

Product Name	O6-(4-Aminomethylbenzyl)Cytosine
CAS No.	1004524-64-4
Molecular Formula	C13H16N4O4
Molecular Weight	292.29 g/mol
Synonyms	4-[[(2-Amino-4-oxo-1,4-dihydro-3-pyrimidinyl)oxy]methyl]benzenemethanamine; O6-(4-Aminobenzyl)cytosine; Cytosine, O6-[(4-aminomethyl)benzyl]-; 1H-Pyrimidin-2-one, 4-amino-6-[[(4-aminomethyl)phenyl]methoxy]-; 4-Amino-6-(((4-(aminomethyl)benzyl)oxy)-1H-pyrimidin-2-one; Research Grade O6-Benzylcytosine Derivative
EINECS	Contact for details

Quality Control

Our O6-(4-Aminomethylbenzyl)Cytosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.