Description

Cyclopropanecarbonyl Chloride, 1-(2,2-Difluoro-1,3-Benzodioxol-5-Yl)- is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluorobenzodioxole and cyclopropanecarbonyl chloride moieties enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate complex, functionalized cyclopropane structures into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and insecticides, leveraging the biological activity of the difluorobenzodioxole group.
• Chemical Research & Development: Serves as a versatile reagent for introducing the cyclopropanecarbonyl group into complex molecules under controlled conditions.
• Ligand and Catalyst Preparation: Employed in the creation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Material Science Precursor: Potential use in synthesizing monomers for specialty polymers with tailored thermal or chemical resistance properties.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 1-(2,2-Difluoro-1,3-Benzodioxol-5-Yl)-
CAS No.	1004294-65-8
Molecular Formula	C11H7ClF2O3
Molecular Weight	260.62 g/mol
Synonyms	1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chloride; 5-(Chlorocarbonylcyclopropyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-5-(1-(chlorocarbonyl)cyclopropyl)-1,3-benzodioxole; Cyclopropanecarbonyl chloride, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-; 1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarbonyl Chloride, 1-(2,2-Difluoro-1,3-Benzodioxol-5-Yl)- adheres to stringent quality protocols suitable for advanced intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure consistency and reliability for your synthetic workflows. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.