Description

4-Methyl-2,3,5-Trifluorobenzoyl Chloride is a high-purity fluorinated benzoyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the reactive acid chloride group, enabling precise molecular modifications to enhance the properties of target compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the trifluoromethyl and fluorine substituents improve lipid solubility and biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and nucleophilic substitution reactions to create complex, fluorinated aromatic structures.
• Material Science Research: Used in developing advanced organic electronic materials and coatings that require specific fluorinated aromatic components.

Basic Information

Product Name	4-Methyl-2,3,5-Trifluorobenzoyl Chloride
CAS No.	1003709-50-9
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2,3,5-Trifluoro-4-methylbenzoyl chloride; 4-Methyl-2,3,5-trifluorobenzoic acid chloride; 2,3,5-Trifluoro-p-toluoyl chloride; 4-Methyl-2,3,5-trifluorobenzenecarbonyl chloride; α,α,α-Trifluoro-4-methyl-2,5-difluorobenzoyl chloride (incorrect but common in searches); Toluoyl chloride, 2,3,5-trifluoro-; Benzoyl chloride, 4-methyl-2,3,5-trifluoro-
EINECS	Contact for details

Quality Control

Our 4-Methyl-2,3,5-Trifluorobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, such as a nitrogen or argon atmosphere, to prevent decomposition. Keep away from heat, open flames, and incompatible materials like strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.