Description

Bms-754807 is a potent and selective small-molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase. This compound is a critical research tool for investigating the IGF-1R signaling pathway, which plays a significant role in cell growth, proliferation, and survival. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, metabolic disorders, and developmental biology for target validation, mechanism of action studies, and preclinical drug discovery.

Application

• Biomedical Research: A key reagent for studying the role of IGF-1R in cancer cell proliferation, survival, and metastasis.
• Drug Discovery & Development: Used as a reference compound or positive control in high-throughput screening assays and in vitro pharmacological profiling for anti-cancer therapeutics.
• Signal Transduction Studies: Essential for elucidating downstream signaling pathways (e.g., PI3K/AKT, MAPK/ERK) activated by IGF-1R in various cell types.
• Academic Research: Employed in university and institutional labs to investigate fundamental biological processes related to growth, development, and metabolism.
• Preclinical Model Validation: Used in animal models to assess the therapeutic potential of IGF-1R inhibition for treating specific cancers.

Basic Information

Product Name	Bms-754807
CAS No.	1001350-96-4
Molecular Formula	C₂₃H₂₃N₅O₃
Molecular Weight	417.46 g/mol
Synonyms	BMS-754807; BMS754807; N-(2-(4-(2,4-Difluorophenoxy)phenyl)propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; IGF-1R Inhibitor (BMS-754807); Insulin-like growth factor 1 receptor inhibitor BMS-754807
EINECS	Contact for details

Quality Control

Our Bms-754807 is manufactured under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation and purity assessment by advanced chromatographic and spectroscopic methods. A Certificate of Analysis (COA) detailing specific results for purity, identity, and other critical parameters is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. For short-term use, the material may be kept at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.