Description

5-Isothiocyanatoquinoline is a versatile heterocyclic building block featuring a reactive isothiocyanate group fused to a quinoline scaffold. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the quinoline moiety for bioactivity.
• Material Science: Acts as a functionalization agent for polymers and surfaces, introducing the isothiocyanate group for further conjugation.
• Chemical Biology & Proteomics: Employed as a labeling reagent or affinity probe due to the specific reactivity of the isothiocyanate group with amines.
• Ligand Synthesis: Utilized in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Dye & Sensor Development: The quinoline core can be exploited to create fluorescent derivatives for sensing applications.

Basic Information

Product Name	5-Isothiocyanatoquinoline
CAS No.	1001183-84-1
Molecular Formula	C10H6N2S
Molecular Weight	186.23 g/mol
Synonyms	Quinoline-5-isothiocyanate; 5-Quinolinyl isothiocyanate; 5-Isothiocyanato-quinoline; Isothiocyanic acid 5-quinolyl ester; 5-ITC-Quinoline; 5-QITC
EINECS	Contact for details

Quality Control

Our 5-Isothiocyanatoquinoline is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.