Description

Xl647 4-Methylbenzenesulfonate is a high-purity organic salt, specifically the tosylate salt form of the compound Xl647. This form is critical for enhancing the stability, solubility, and bioavailability of the active pharmaceutical ingredient (API) in formulation development. It is primarily utilized by pharmaceutical R&D and manufacturing organizations engaged in the development of targeted kinase inhibitors for oncology applications.

Application

• Pharmaceutical Intermediate: Serves as a key salt form in the synthesis and final formulation of the investigational drug candidate Xl647.
• Oncology Research: Used in preclinical and clinical research for developing tyrosine kinase inhibitors targeting EGFR, VEGFR, and other kinases.
• API Salt Formation: Employed to improve the physicochemical properties of the base API, such as crystallinity and handling characteristics.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in regulatory filings.
• Drug Formulation Studies: Utilized in stability studies, dosage form development (e.g., tablets, capsules), and bioavailability enhancement projects.

Basic Information

Product Name	Xl647 4-Methylbenzenesulfonate
CAS No.	1000599-06-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Xl647 Tosylate; Xl647 p-Toluenesulfonate Salt; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide 4-Methylbenzenesulfonate; XL647 Tosylate Salt; EXEL-647 Tosylate; Kinase Inhibitor XL647 Tosylate
EINECS	Contact for details

Quality Control

Our Xl647 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods to ensure it meets stringent specifications for pharmaceutical development. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.