Description

4-Bromo-2,5-Difluorophenylisothiocyanate is a versatile and highly reactive aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of bromine, fluorine substituents, and the reactive isothiocyanate group, enabling precise molecular construction for complex targets. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides, leveraging the bioactivity of fluorine and sulfur-containing motifs.
• Ligand and Material Science: Serves as a precursor for synthesizing specialized ligands for catalysis and as a monomer for advanced polymers.
• Chemical Biology Probe Development: The reactive isothiocyanate group is utilized for bioconjugation and labeling of proteins or other biomolecules.
• Heterocyclic Compound Synthesis: A crucial starting material for constructing complex sulfur and nitrogen-containing heterocycles like benzothiazoles and thiazolidinones.

Basic Information

Product Name	4-Bromo-2,5-Difluorophenylisothiocyanate
CAS No.	1000577-80-9
Molecular Formula	C7H2BrF2NS
Molecular Weight	250.07 g/mol
Synonyms	2,5-Difluoro-4-bromophenyl isothiocyanate; 1-Bromo-2,5-difluoro-4-isothiocyanatobenzene; 4-Bromo-2,5-difluorobenzene isothiocyanate; Isothiocyanic acid, 4-bromo-2,5-difluorophenyl ester; 4-Bromo-2,5-difluorophenyl mustard oil; (4-Bromo-2,5-difluorophenyl)isothiocyanate
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,5-Difluorophenylisothiocyanate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. We are committed to meeting the stringent requirements of research and cGMP-grade production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.