Description

2-Bromo-4-Chloro-6-Fluorophenylisothiocyanate is a high-purity, multi-halogenated aromatic isothiocyanate building block of significant synthetic utility. This compound is valued for its role as a key precursor in the synthesis of complex heterocyclic systems and advanced pharmaceutical intermediates. It is primarily required by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Chemical Biology Probe Development: Serves as a reactive handle for bioconjugation and the creation of activity-based probes (ABPs) due to the electrophilic isothiocyanate group.
• Material Science Research: Employed in the synthesis of specialized polymers, liquid crystals, and organic electronic materials where halogen and sulfur functionalities are desired.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-Bromo-4-Chloro-6-Fluorophenylisothiocyanate
CAS No.	1000577-50-3
Molecular Formula	C7H2BrClFNS
Molecular Weight	282.52 g/mol
Synonyms	1-Bromo-3-chloro-5-fluorophenyl isothiocyanate; (2-Bromo-4-chloro-6-fluorophenyl)isothiocyanate; 2-Bromo-4-chloro-6-fluoro-1-isothiocyanatobenzene; Isothiocyanic acid, 2-bromo-4-chloro-6-fluorophenyl ester; 2-Bromo-4-chloro-6-fluorobenzene isothiocyanate
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Chloro-6-Fluorophenylisothiocyanate is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (NMR, IR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.