Description

2-Bromo-4-Fluoro-6-Methylphenylisothiocyanate is a specialized aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique bifunctional reactivity, where the isothiocyanate group acts as a versatile electrophile for constructing heterocycles and the halogenated aromatic core provides a handle for further functionalization via cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting neurological disorders and oncology.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Material Science: Used to create specialized ligands for catalysis and as a monomer for advanced polymeric materials.
• Chemical Biology Probe Development: Serves as a reactive handle for labeling proteins or other biomolecules due to the isothiocyanate group's affinity for amines.
• Heterocyclic Chemistry: Fundamental starting material for constructing benzothiazole, thiourea, and other sulfur- and nitrogen-containing heterocycles.

Basic Information

Product Name	2-Bromo-4-Fluoro-6-Methylphenylisothiocyanate
CAS No.	1000576-56-6
Molecular Formula	C8H5BrFNS
Molecular Weight	246.10 g/mol
Synonyms	1-Bromo-3-fluoro-5-isothiocyanato-2-methylbenzene; 2-Methyl-4-fluoro-6-bromophenyl isothiocyanate; (2-Bromo-4-fluoro-6-methylphenyl) isothiocyanate; Isothiocyanic acid, 2-bromo-4-fluoro-6-methylphenyl ester; 6-Bromo-2-fluoro-4-methylphenyl isothiocyanate; SCN-C6H2(Br)(F)(CH3)
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoro-6-Methylphenylisothiocyanate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment is to supply material that meets the exacting standards required for research and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.