Description

Voruciclib is a potent and selective small-molecule inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK9. This compound is a critical research tool and a promising candidate in the development of novel therapeutics for oncology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in cancer research and drug discovery. Voruciclib CAS NO 1000023-04-0 represents a high-purity chemical entity essential for advancing studies in transcriptional regulation and apoptosis.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of CDK9-targeted cancer therapies.
• Preclinical Cancer Studies: For in vitro and in vivo investigation of its efficacy against various cancer cell lines, including hematological malignancies and solid tumors.
• Mechanistic Biology Research: Used to study the role of CDK9 in transcriptional elongation, cell cycle control, and apoptosis signaling pathways.
• Biochemical Assay Development: Serves as a standard inhibitor in kinase selectivity panels and high-throughput screening (HTS) assays to discover new drug candidates.
• Combination Therapy Research: Investigated in synergy studies with other chemotherapeutic agents or targeted therapies to overcome drug resistance.

Basic Information

Product Name	Voruciclib
CAS No.	1000023-04-0
Molecular Formula	C₂₀H₂₀N₈O
Molecular Weight	388.42 g/mol
Synonyms	P1446A-05; (S)-6-(2-Chlorophenyl)-8-ethoxy-2-(3-(hydroxymethyl)piperidin-1-yl)pyrido[2,3-d]pyrimidin-7(8H)-one; CDK9 Inhibitor; SEL120-34A; P-1446A-05
EINECS	Contact for details

Quality Control

Our Voruciclib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific pharmacopeial or client requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.