Description

2'-o-(tert-Butyldimethylsilyl)-N6-Methyladenosine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis and pharmaceutical research. This compound is critical for enabling precise chemical modifications in RNA and nucleotide analogs, which are fundamental to developing novel therapeutics and diagnostic tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on antisense oligonucleotides, siRNA, and mRNA technology.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a crucial building block for introducing N6-methyladenosine (m6A) modifications into synthetic RNA strands.
• Pharmaceutical Intermediate: Used in the research and development of novel nucleoside-based therapeutics, including antiviral and anticancer agents.
• Biochemical Research: A vital tool for studying RNA structure, function, and epigenetics, particularly the role of m6A modifications.
• Probe and Diagnostic Development: Employed in the synthesis of labeled nucleotides for use in diagnostic assays and molecular probes.
• Process Development: Acts as a high-purity intermediate for scaling up the production of modified oligonucleotides under GMP conditions.

Basic Information

Product Name	2'-o-(tert-Butyldimethylsilyl)-N6-Methyladenosine
CAS No.	1000001-83-1
Molecular Formula	C₁₈H₃₁N₅O₅Si
Molecular Weight	425.56 g/mol
Synonyms	2'-O-TBDMS-N6-Methyladenosine; N6-Methyl-2'-O-(tert-butyldimethylsilyl)adenosine; 2'-O-(tert-Butyldimethylsilyl)-N(6)-methyladenosine; 2'-O-TBDMS-m6A; N6-Methyladenosine 2'-O-TBDMS ether; 2'-O-(tert-Butyldimethylsilyl)-6-methylaminopurine riboside; Protected N6-Methyladenosine; m6A-TBDMS
EINECS	Contact for details

Quality Control

Every batch of 2'-o-(tert-Butyldimethylsilyl)-N6-Methyladenosine is manufactured and tested to meet stringent quality standards suitable for research and pharmaceutical applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, supporting compliance with internal specifications and research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.