Description

Fmoc Isothiocyanate CAS NO 199915-38-3 is a specialized amino acid derivative and a key reagent in modern peptide synthesis. It is primarily used for the efficient and selective introduction of the Fmoc (9-fluorenylmethoxycarbonyl) protecting group onto amine functionalities. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity building blocks for solid-phase peptide synthesis (SPPS) and other advanced organic syntheses.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the preparation of Fmoc-protected amino acids, which are the standard building blocks in Fmoc-based SPPS methodologies.
• Protecting Group Chemistry: Used for the selective protection of primary and secondary amines in complex multi-step organic syntheses, particularly in medicinal chemistry.
• Bioconjugation: Serves as a versatile linker for coupling peptides, proteins, or other amine-containing molecules to solid supports, fluorescent tags, or drug delivery systems.
• Pharmaceutical Intermediate: A critical raw material in the research and development of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Material Science: Can be used to functionalize surfaces or polymers with amine-reactive groups for creating advanced biomaterials.

Basic Information

Product Name	Fmoc Isothiocyanate
CAS No.	199915-38-3
Molecular Formula	C₁₆H₁₁NO₂S
Molecular Weight	281.33 g/mol
Synonyms	9-Fluorenylmethyl Isothiocyanate; FMOC-NCS; N-(9-Fluorenylmethoxycarbonyl) Isothiocyanate; (9H-Fluoren-9-yl)methyl Isothiocyanate; Fmoc-NCS; Fmoc-isothiocyanate; 9-Fluorenylmethoxycarbonyl Isothiocyanate; 9-Fmoc Isothiocyanate
EINECS	Contact for details

Quality Control

Our Fmoc Isothiocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and production applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC), identity (by IR and NMR), and moisture content. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.