Description

5-Amino-3-β-D-Ribofuranosylthiazolo[4,5-D]Pyrimidine-2,7(3H,6H)-Dione Monohydrate is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound matters as a critical synthetic intermediate for the creation of novel antiviral and anticancer agents, particularly those targeting nucleic acid synthesis and function. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of modified nucleosides and nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies of enzyme inhibition, nucleic acid metabolism, and mechanism of action for therapeutic agents.
• Antiviral Drug Development: Serves as a precursor in the research and production of potential drugs targeting viral polymerases (e.g., for hepatitis, herpesviruses).
• Oncology Research: Investigated for incorporation into chemotherapeutic agents that disrupt DNA/RNA synthesis in cancer cells.
• Pro-drug Synthesis: Utilized in the development of nucleoside pro-drugs designed for improved bioavailability and targeted delivery.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental medicinal chemistry and drug discovery projects.

Basic Information

Product Name	5-Amino-3-β-D-Ribofuranosylthiazolo[4,5-D]Pyrimidine-2,7(3H,6H)-Dione Monohydrate
CAS No.	198832-38-1
Molecular Formula	C11H14N4O7S • H2O
Molecular Weight	348.32 g/mol (Monohydrate)
Synonyms	5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione monohydrate; Thiazolo[4,5-d]pyrimidine nucleoside derivative; 2-Amino-4,7-dihydro-4-hydroxy-7-oxo-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine monohydrate; 5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine-2,7-dione hydrate; Nucleoside thiazolopyrimidine analog; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 5-Amino-3-β-D-Ribofuranosylthiazolo[4,5-D]Pyrimidine-2,7(3H,6H)-Dione Monohydrate is manufactured under strict quality control protocols suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR). Certificates of Analysis (COA) detailing batch-specific results are available upon request to ensure traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	4.5% - 6.5% (Theoretical for monohydrate: ~5.2%)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.