Description

Fmoc-D-Leu-Cl CAS NO 198544-60-4 is a high-purity, chiral amino acid derivative specifically designed for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of D-leucine residues, enabling the creation of complex peptides with enhanced stability and biological activity. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic research focused on developing novel therapeutic peptides, peptidomimetics, and proteomics tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid chloride, it is used for the efficient, racemization-free coupling of D-leucine in automated and manual peptide synthesizers.
• Pharmaceutical Intermediate: A key precursor in the research and development of peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Labeling: Useful for incorporating D-leucine tags into proteins or other biomolecules for structural studies, imaging, or diagnostic applications.
• Combinatorial Chemistry Libraries: Employed to generate diverse libraries of peptide compounds for high-throughput screening in drug discovery campaigns.
• Academic and Industrial Research: Fundamental reagent for studying peptide structure-activity relationships, chirality effects, and developing new synthetic methodologies.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of non-natural and difficult-sequence peptides for clients.

Basic Information

Product Name	Fmoc-D-Leu-Cl
CAS No.	198544-60-4
Molecular Formula	C22H24ClNO4
Molecular Weight	401.88 g/mol
Synonyms	Fmoc-D-leucine chloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucinyl chloride; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoyl chloride; D-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, chloride; Fmoc-D-Leu-OCl; N-Fmoc-D-leucine acid chloride
EINECS	Contact for details

Quality Control

Our Fmoc-D-Leu-Cl is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive peptide synthesis applications. Each batch is analyzed using advanced techniques like HPLC, NMR, and optical rotation to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in GMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.