Description

Tigecycline Hydrochloride CAS NO 197654-04-9 is a semisynthetic glycylcycline antibiotic derived from minocycline. It is a critical active pharmaceutical ingredient (API) valued for its broad-spectrum activity against multidrug-resistant Gram-positive and Gram-negative pathogens. This compound is essential for pharmaceutical manufacturers developing injectable antibiotic formulations to treat complicated skin, skin structure, and intra-abdominal infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Hospital-Acquired Infection Treatment: Formulation into drugs targeting complicated intra-abdominal infections (cIAI) and complicated skin and skin structure infections (cSSSI).
• Antibiotic Resistance Management: A key therapeutic agent in the global fight against bacteria resistant to tetracyclines and other antibiotics.
• Research & Development: Used in microbiological research, preclinical studies, and the development of new combination therapies.
• Reference Standard: Serves as a high-purity chemical standard for quality control and analytical testing in pharmaceutical labs.

Basic Information

Product Name	Tigecycline Hydrochloride
CAS No.	197654-04-9
Molecular Formula	C29H39N5O8 • HCl
Molecular Weight	606.11 g/mol (for free base: 569.65 g/mol)
Synonyms	(9-t-Butylglycylamido-minocycline) Hydrochloride; Tygacil (Brand Name); GAR-936; TBG-MINO; (4S,4aS,5aR,12aS)-9-[2-(tert-Butylamino)acetamido]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide Hydrochloride
EINECS	Contact for details

Quality Control

Our Tigecycline Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange amorphous powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Microbial Enumeration	Meets Ph. Eur./USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.