Description

Atrasentan Hydrochloride is a potent and selective endothelin A (ETA) receptor antagonist, a critical research compound for investigating cardiovascular and renal pathologies. Its high selectivity makes it an invaluable pharmacological tool for studying endothelin-mediated signaling pathways and developing novel therapeutic agents. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiorenal disease, oncology, and fibrosis research.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in analytical method development and validation for drug substance and product testing.
• Preclinical Research: A key tool compound for in vitro and in vivo studies targeting the endothelin system in cardiovascular and renal disease models.
• Mechanistic Studies: Employed to elucidate the role of ETA receptors in disease progression, including hypertension, diabetic nephropathy, and pulmonary arterial hypertension.
• Oncology Research: Investigated for its potential anti-cancer effects, particularly in prostate cancer and other malignancies where endothelin signaling is implicated.
• Biochemical Assay Development: Serves as a critical component in high-throughput screening (HTS) campaigns and receptor binding assays to discover new ETA antagonists.
• Metabolite Identification & PK/PD Studies: Used in pharmacokinetic, pharmacodynamic, and metabolism studies to support drug development programs.

Basic Information

Product Name	Atrasentan Hydrochloride
CAS No.	195733-43-8
Molecular Formula	C29H38N2O6 • HCl
Molecular Weight	547.08 g/mol
Synonyms	ABT-627 Hydrochloride; (+)-A-127722; Atrasentan HCl; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride; ABT-627; A-147627
EINECS	Contact for details

Quality Control

Our Atrasentan Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications. We support development efforts with materials suitable for use as pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.