Description

Amphotericin B, n-(1-Deoxy-D-Fructos-1-Yl)-n-Methyl-, Methyl Ester, L- Aspartate (1:1) (Salt) is a chemically modified derivative of the potent polyene macrolide antifungal agent, Amphotericin B. This specific salt form is engineered to enhance solubility and stability, addressing key formulation challenges associated with the parent compound. It is a critical intermediate and active pharmaceutical ingredient (API) for advanced pharmaceutical research and development, particularly in creating novel antifungal therapies. Professionals in pharmaceutical R&D, process chemistry, and advanced drug delivery systems require this high-purity compound for developing next-generation treatments.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel, semi-synthetic antifungal agents with potentially improved therapeutic profiles.
• Antifungal Drug Development: Used in R&D for formulating new dosage forms, such as liposomal or lipid complex preparations, to reduce toxicity and improve efficacy.
• Biomedical Research: Employed as a reference standard and tool compound in microbiological and pharmacological studies to investigate fungal cell membrane interactions.
• Process Chemistry & Scale-Up: Utilized in process development and optimization for the commercial manufacturing of antifungal APIs.
• Drug Delivery System Research: Investigated in advanced delivery platforms aimed at targeted release and reduced nephrotoxicity.

Basic Information

Product Name	Amphotericin B, n-(1-Deoxy-D-Fructos-1-Yl)-n-Methyl-, Methyl Ester, L- Aspartate (1:1) (Salt)
CAS No.	195193-90-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Amphotericin B Methyl Ester Aspartate Salt; N-Methyl-N-(1-deoxy-D-fructos-1-yl)amphotericin B methyl ester L-aspartate salt; Amphotericin B fructosamine methyl ester aspartate; Modified Amphotericin B aspartate salt; Antifungal derivative aspartate salt; Polyene macrolide derivative salt; API Intermediate 195193-90-9
EINECS	Contact for details

Quality Control

Our Amphotericin B derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and tests for specific impurities and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.