Description

1-((2R,3R,4R,5R)-5-(Aminomethyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione is a high-purity nucleoside analogue with a defined stereochemistry, making it a critical building block for advanced pharmaceutical research and synthesis. This compound is essential for the development of novel antiviral and anticancer therapeutics, where precise molecular structure is paramount for biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of nucleoside-based active pharmaceutical ingredients (APIs) and prodrugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Research: Used as a precursor in the development of novel therapeutics targeting viral polymerases and reverse transcriptases.
• Oncology Research: Investigated as a building block for creating nucleoside analogues that interfere with cancer cell DNA/RNA synthesis.
• Prodrug Development: Employed in the design and synthesis of prodrugs to enhance the bioavailability and targeting of nucleoside therapeutics.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Fine Chemical Synthesis: Acts as a specialized starting material for custom synthesis and contract manufacturing of high-value chemical entities.

Basic Information

Product Name	1-((2R,3R,4R,5R)-5-(Aminomethyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	194034-69-0
Molecular Formula	C11H15N3O6
Molecular Weight	285.25 g/mol
Synonyms	(2R,3R,4R,5R)-5-(Aminomethyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-yl Uracil; 5'-Aminomethyl-2',3'-Dideoxy-3'-Methoxyuridine; 1-[(2R,3R,4R,5R)-5-(Aminomethyl)-4-Hydroxy-3-Methoxytetrahydro-2-Furanyl]-2,4(1H,3H)-Pyrimidinedione; 3'-Methoxy-5'-aminomethyl-2',3'-dideoxyuridine; Uracil, 1-[(2R,3R,4R,5R)-5-(aminomethyl)-4-hydroxy-3-methoxytetrahydro-2-furanyl]-
EINECS	Contact for details

Quality Control

Our 1-((2R,3R,4R,5R)-5-(Aminomethyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.