Description

2,4,5-Trifluorophenacyl Bromid is a versatile fluorinated organic building block of significant interest in advanced chemical synthesis. Its value lies in its role as a key electrophilic intermediate for introducing the phenacyl moiety into complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its trifluoromethyl and bromine substituents offer unique reactivity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the biological activity imparted by the fluorine atoms.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals, where it modifies thermal stability and optical properties.
• Chemical Biology Probes: Utilized to create activity-based probes and fluorogenic substrates for enzyme activity studies.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for fine chemical manufacturers offering bespoke synthesis services to clients in life sciences.

Basic Information

Product Name	2,4,5-Trifluorophenacyl Bromid
CAS No.	193977-34-3
Molecular Formula	C8H4BrF3O
Molecular Weight	253.02 g/mol
Synonyms	2-Bromo-1-(2,4,5-trifluorophenyl)ethan-1-one; 2,4,5-Trifluorophenacyl bromide; 1-(2,4,5-Trifluorophenyl)-2-bromoethanone; α-Bromo-2,4,5-trifluoroacetophenone; 2,4,5-Trifluoro-ω-bromoacetophenone; 2-Bromo-2',4',5'-trifluoroacetophenone; Ethanone, 2-bromo-1-(2,4,5-trifluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 2,4,5-Trifluorophenacyl Bromid is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by advanced analytical techniques, is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.