Description

1-Azabicyclo[2.2.1]Heptane-3-Carbonyl Chloride, (1R-Endo)- (9Ci) is a high-value, stereochemically defined bicyclic building block used in advanced organic synthesis. This compound is critical for the development of novel pharmaceuticals and agrochemicals due to its rigid, three-dimensional scaffold and reactive acid chloride functionality. It is primarily sought after by research and development chemists in the pharmaceutical industry for constructing complex molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its bicyclic structure can contribute to unique modes of action.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Potential monomer or cross-linking agent for developing specialty polymers with specific structural properties.

Basic Information

Product Name	1-Azabicyclo[2.2.1]Heptane-3-Carbonyl Chloride, (1R-Endo)- (9Ci)
CAS No.	193674-17-8
Molecular Formula	C7H10ClNO
Molecular Weight	159.61 g/mol
Synonyms	(1R,3R,4S)-3-(Chlorocarbonyl)-2-azabicyclo[2.2.1]heptane; (1R,3R,4S)-2-Azabicyclo[2.2.1]heptane-3-carbonyl chloride; endo-(1R)-3-Carbamoyl-2-azabicyclo[2.2.1]heptane chloride; 2-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, (1R,3R,4S)-; Bicyclic Proline Acid Chloride Derivative; (1R-Endo)-3-Carboxy-2-azabicyclo[2.2.1]heptanoyl chloride
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[2.2.1]Heptane-3-Carbonyl Chloride, (1R-Endo)- (9Ci) is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.