Description

3-Pyridinecarbonyl Chloride, 6-Methoxy- (9Ci) is a versatile and reactive heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 6-methoxynicotinoyl moiety, a key structural motif in pharmaceutical and agrochemical research. This high-purity intermediate is essential for medicinal chemists and process development scientists working on novel active ingredients, particularly in the development of kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require the 6-methoxynicotinoyl pharmacophore.
• Chemical Biology & Proteomics: Employed as a coupling agent or labeling reagent for modifying proteins, peptides, or other biomolecules.
• Material Science: Monomer or precursor for synthesizing specialty polymers, liquid crystals, or organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up development.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 6-Methoxy- (9Ci)
CAS No.	193538-78-2
Molecular Formula	C7H6ClNO2
Molecular Weight	171.58 g/mol
Synonyms	6-Methoxynicotinoyl chloride; 6-Methoxypyridine-3-carbonyl chloride; 6-Methoxy-3-pyridinecarboxylic acid chloride; 6-Methoxynicotinic acid chloride; 6-Methoxy-3-pyridinylcarbonyl chloride; 6-Methoxynicotinic acid, chloride; 3-Carboxy-6-methoxypyridine chloride
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarbonyl Chloride, 6-Methoxy- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.