Description

Lonafarnib CAS NO 193275-86-4 is a potent and selective farnesyltransferase inhibitor (FTI) with significant therapeutic potential. This small molecule compound is critical for researchers and pharmaceutical developers targeting specific cellular pathways. It is primarily utilized in advanced pharmaceutical research and development, particularly for investigating treatments in oncology and genetic disorders such as progeria.

Application

• Pharmaceutical R&D (Oncology): Investigational agent for targeting Ras-dependent cancers by inhibiting protein farnesylation.
• Rare Disease Research: Key compound in clinical studies for Hutchinson-Gilford Progeria Syndrome (HGPS) and related progeroid laminopathies.
• Mechanistic Studies: Used as a biochemical tool to study the farnesyltransferase enzyme pathway and its role in cell signaling and maturation.
• Preclinical Development: Serves as a reference standard and active pharmaceutical ingredient (API) in formulation and pharmacokinetic studies.
• Virology Research: Investigated for potential antiviral applications, including against hepatitis delta virus (HDV).

Basic Information

Product Name	Lonafarnib
CAS No.	193275-86-4
Molecular Formula	C27H31Br2NO4
Molecular Weight	593.35 g/mol
Synonyms	SCH 66336; Sarasar; (R)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; 4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]piperidinecarboxamide; Farnesyltransferase Inhibitor SCH66336
EINECS	Contact for details

Quality Control

Our Lonafarnib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of residual solvents and impurities to meet high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (HPLC)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.