Description

Lonafarnib CAS NO 193275-84-2 is a potent and selective farnesyltransferase inhibitor (FTI) that has been extensively studied for its therapeutic potential. This small molecule compound is critical for researchers and pharmaceutical developers targeting specific protein prenylation pathways. It is primarily utilized in advanced pharmaceutical research, clinical development, and as a key reference standard in analytical laboratories.

Application

• Oncology Research: Investigated as a potential therapeutic agent for various cancers, including progeria (Hutchinson-Gilford Progeria Syndrome) and certain solid tumors, by inhibiting the farnesylation of proteins like progerin and RAS.
• Antiviral Research: Studied for activity against viruses such as Hepatitis Delta Virus (HDV), where farnesylation of the viral large delta antigen is essential for replication.
• Pharmaceutical Intermediate: Serves as a high-purity building block in the synthesis of more complex drug candidates and novel FTI derivatives.
• Reference Standard: Used as a certified reference material (CRM) in analytical testing, method development, and quality control for pharmaceutical manufacturing to ensure product identity and purity.
• Biochemical & Cell Biology Studies: A vital tool for elucidating the role of protein farnesylation in cell signaling, proliferation, and disease mechanisms in academic and industrial R&D settings.

Basic Information

Product Name	Lonafarnib
CAS No.	193275-84-2
Molecular Formula	C27H31Br2NO4
Molecular Weight	593.35 g/mol
Synonyms	SCH 66336; Sarasar; 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide; (R)-4-(2-(4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide; FTI-277 (related analog); Farnesyltransferase Inhibitor SCH66336
EINECS	Contact for details

Quality Control

Our Lonafarnib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and impurities to meet research-grade and potential GMP-starting material standards. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (HPLC)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.