Description

3',5',N2-Tri-o-Acetyl-2'-Deoxyguanosine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides and modified DNA sequences. This compound matters because it provides a stable, reactive intermediate that prevents unwanted side reactions during complex chemical synthesis, ensuring high yield and purity of the final product. It is primarily needed by research institutions and pharmaceutical companies engaged in antiviral drug development, antisense oligonucleotide production, and genetic research.

Application

• Solid-phase oligonucleotide synthesis as a crucial building block (phosphoramidite precursor).
• Research and development of antisense therapeutics and siRNA molecules.
• Chemical synthesis of nucleoside prodrugs and analogs for antiviral and anticancer applications.
• Preparation of fluorescently-labeled or modified nucleotides for diagnostic probes.
• Use in medicinal chemistry for structure-activity relationship (SAR) studies.
• Scale-up production for Active Pharmaceutical Ingredient (API) manufacturing processes.

Basic Information

Product Name	3',5',N2-Tri-o-Acetyl-2'-Deoxyguanosine
CAS No.	193092-29-4
Molecular Formula	C₁₇H₂₁N₅O₇
Molecular Weight	407.38 g/mol
Synonyms	2'-Deoxyguanosine, 3',5',N2-triacetate; 2'-Deoxy-N2,3',5'-tri-O-acetylguanosine; 1-[(2R,4S,5R)-4-Acetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl]-2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-one; N2,3',5'-Tri-O-acetyl-2'-deoxyguanosine; dG(Ac)3; Protected 2'-Deoxyguanosine
EINECS	Contact for details

Quality Control

Our 3',5',N2-Tri-o-Acetyl-2'-Deoxyguanosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.