Description

Prinomastat is a potent and selective synthetic inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP-2, MMP-9, and MMP-13. This compound is of significant interest in pharmaceutical research for its potential role in modulating tissue remodeling and pathological processes. It serves as a critical research chemical for scientists in oncology, cardiology, and neurology, particularly in studies related to cancer metastasis, atherosclerosis, and neurodegenerative diseases. Prinomastat CAS NO 192329-42-3 represents a high-purity tool for advancing therapeutic discovery and mechanistic studies.

Application

• Oncology Research: Investigation of tumor invasion, angiogenesis, and metastasis by inhibiting key MMPs involved in extracellular matrix degradation.
• Cardiovascular Disease Studies: Research into atherosclerotic plaque stability and cardiac remodeling post-myocardial infarction.
• Neurological Research: Exploration of its effects in models of neuroinflammation, multiple sclerosis, and Alzheimer's disease.
• Arthritis and Connective Tissue Disorder Research: Study of cartilage degradation and joint pathology in rheumatoid and osteoarthritis models.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Preclinical Drug Development: Serves as a lead compound or pharmacologic tool for structure-activity relationship (SAR) studies and novel therapeutic agent design.

Basic Information

Product Name	Prinomastat
CAS No.	192329-42-3
Molecular Formula	C20H21N3O4
Molecular Weight	367.40 g/mol
Synonyms	AG3340; CGS 27023A; (S)-2-(4'-Bromobiphenyl-4-sulfonylamino)-3-methylbutyric acid 2-methoxyethyl ester; Prinomastat hydrochloride; MMP Inhibitor III; N-Hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide
EINECS	Contact for details

Quality Control

Our Prinomastat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be customized to meet the requirements of GMP or other advanced pharmaceutical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.