Description

1-Cyclopropyl-3-(Trimethylsilyl)Prop-2-Yn-1-Ol is a specialized organosilicon building block featuring both a cyclopropyl and a protected terminal alkyne group. This unique molecular architecture makes it a valuable intermediate for constructing complex frameworks in advanced synthetic chemistry. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of complex drug candidates, particularly those requiring cyclopropane or alkyne functional groups.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its reactive alkyne moiety for coupling reactions.
• Material Science Research: Serves as a precursor for novel polymers or functionalized surfaces where the silyl-protected alkyne allows for controlled polymerization or grafting.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Glaser, or other metal-catalyzed coupling reactions to form extended conjugated systems.
• Ligand and Catalyst Development: Utilized for the preparation of specialized ligands or organometallic catalysts in asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of molecular probes where the alkyne handle is used for bioorthogonal labeling via click chemistry.

Basic Information

Product Name	1-Cyclopropyl-3-(Trimethylsilyl)Prop-2-Yn-1-Ol
CAS No.	192315-00-7
Molecular Formula	C9H16OSi
Molecular Weight	168.31 g/mol
Synonyms	1-Cyclopropyl-3-(trimethylsilyl)-2-propyn-1-ol; 3-Trimethylsilyl-1-cyclopropylprop-2-yn-1-ol; 1-Cyclopropyl-3-(trimethylsilyl)prop-2-yn-1-ol; (1-Cyclopropyl-3-trimethylsilylprop-2-ynyl)alcohol; TMS-Cyclopropyl Propargyl Alcohol; Cyclopropyl(trimethylsilylethynyl)methanol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Quality is verified through advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.