Description

7α,27-Dihydroxy-4-Cholesten-3-One is a specialized oxysterol derivative, a key intermediate in the bile acid biosynthesis pathway. This compound is of significant interest for its role in cholesterol metabolism research and as a critical building block for synthesizing more complex steroidal molecules. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on metabolic studies and novel therapeutic development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of bile acids and other bioactive sterols for drug discovery programs.
• Biochemical Research: Used as a reference standard and probe in studies of cholesterol 7α-hydroxylase and sterol 27-hydroxylase enzyme activities.
• Metabolic Pathway Analysis: Essential for investigating alternative pathways of bile acid synthesis and cholesterol homeostasis in vitro and in vivo.
• Reference Material: Serves as a high-purity analytical standard for LC-MS, HPLC, and other chromatographic methods in clinical and research laboratories.
• Fine Chemical Synthesis: Employed as a starting material for the custom synthesis of labeled (e.g., deuterated, 13C) sterol derivatives for tracer studies.

Basic Information

Product Name	7α,27-Dihydroxy-4-Cholesten-3-One
CAS No.	192187-67-0
Molecular Formula	C27H44O3
Molecular Weight	416.64 g/mol
Synonyms	3-Oxo-7α,27-dihydroxycholest-4-ene; 4-Cholesten-7α,27-diol-3-one; 7α,27-Dihydroxycholest-4-en-3-one; (7α,25R)-7,26-Dihydroxycholest-4-en-3-one; 7α,27-Dihydroxy-5β-cholestan-3-one (related saturated form); Oxysterol metabolite
EINECS	Contact for details

Quality Control

We supply 7α,27-Dihydroxy-4-Cholesten-3-One with a focus on high purity and batch-to-batch consistency, essential for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC are available upon request. We adhere to cGMP principles for manufacturing and documentation where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.