Description

Tipifarnib (S Enantiomer) is a highly potent and selective farnesyltransferase inhibitor, representing the biologically active enantiomer of the compound. This specificity is critical for advanced pharmaceutical research and development, particularly in the study of targeted cancer therapies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Oncology Research: A key reference standard and active pharmaceutical ingredient (API) in the investigation of farnesyltransferase inhibition for cancer treatment.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and mechanism of action.
• Pharmaceutical Intermediates: Serves as a critical chiral building block in the synthesis of more complex therapeutic agents.
• Biochemical Assays: Employed as a selective inhibitor to study Ras protein signaling pathways and related oncogenic processes.
• Reference Standard: Used for analytical purposes, including method development, validation, and quality control in pharmaceutical analysis (HPLC, LC-MS).
• Academic Research: Supports fundamental research in cell biology, signal transduction, and targeted therapy mechanisms.

Basic Information

Item	Detail
Product Name	Tipifarnib (S Enantiomer)
CAS No.	192185-71-0
Molecular Formula	C27H29Cl2N3O4
Molecular Weight	522.45 g/mol
Synonyms	(S)-Tipifarnib; (S)-Enantiomer of R115777; (S)-6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; Zarnestra (S-Form); R115777 (S-Enantiomer); (S)-4-(3-Chlorophenyl)-6-[(R)-(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methylamino]-1-methylquinolin-2(1H)-one
EINECS	Contact for details

Quality Control

Every batch of Tipifarnib (S Enantiomer) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and enantiomeric excess meet the rigorous standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results for assay, chiral purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-Enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.