Description

2-Methoxy-5-(trifluoromethoxy)benzoyl chloride is a high-value, multi-functional aromatic acid chloride intermediate. This compound matters for its unique chemical structure, which combines methoxy and trifluoromethoxy substituents to impart specific electronic and steric properties, making it a critical building block for advanced synthesis. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly those requiring the introduction of a benzoyl group with enhanced lipophilicity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group contributes to improved biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for mesogens and electron-transport materials in display technologies and organic light-emitting diodes.
• Polymer Chemistry: Acts as a monomer or modifying agent for engineering plastics and high-performance polymers with specific thermal and chemical resistance properties.
• Custom Synthesis & Contract Manufacturing: Employed by fine chemical companies for the custom synthesis of specialty chemicals and complex organic molecules for various industrial clients.
• Research & Development: Essential reagent in academic and industrial laboratories for methodological development and exploring new chemical spaces in organic chemistry.

Basic Information

Product Name	2-Methoxy-5-(trifluoromethoxy)benzoyl Chloride
CAS No.	191604-91-8
Molecular Formula	C9H6ClF3O3
Molecular Weight	254.59 g/mol
Synonyms	5-(Trifluoromethoxy)-2-methoxybenzoyl chloride; 2-Methoxy-5-(trifluoromethoxy)benzoic acid chloride; 2-Methoxy-α,α,α-trifluoro-p-anisoyl chloride; 2-Methoxy-5-trifluoromethoxybenzoyl chloride; Benzoyl chloride, 2-methoxy-5-(trifluoromethoxy)-; 5-Trifluoromethoxy-o-anisoyl chloride
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(trifluoromethoxy)benzoyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for sensitive pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts vigorously with strong acids and organic solvents; ensure the container is kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.