Description

(S)-3-Acetoxy-4-Bromobutyryl Chloride is a high-purity chiral building block and key synthetic intermediate. This compound is valued for its reactive acid chloride and bromo functionalities, enabling precise stereoselective synthesis in complex molecule construction. It is primarily required by research and development chemists in the pharmaceutical and agrochemical industries for the production of active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in cardiovascular and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced, stereospecific pesticides and herbicides.
• Peptide Mimetics & Conjugate Chemistry: Serves as a versatile linker or coupling agent for creating peptide-based compounds and antibody-drug conjugates (ADCs).
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to introduce chiral centers with high enantiomeric purity.
• Material Science Research: Utilized in the development of specialty polymers and liquid crystals where specific chirality is required.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	(S)-3-Acetoxy-4-Bromobutyryl Chloride
CAS No.	191354-46-8
Molecular Formula	C6H8BrClO3
Molecular Weight	243.48 g/mol
Synonyms	(S)-4-Bromo-3-acetoxybutyryl chloride; (3S)-4-Bromo-3-acetoxybutanoyl chloride; (S)-(-)-3-Acetoxy-4-bromobutyryl chloride; 4-Bromo-3-acetoxybutyryl chloride, (S)-; Butanoyl chloride, 4-bromo-3-acetoxy-, (3S)-; (S)-3-Acetoxy-4-bromobutyroyl chloride; (S)-3-Acetyloxy-4-bromobutyryl chloride
EINECS	Contact for details

Quality Control

Our (S)-3-Acetoxy-4-Bromobutyryl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) verification by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a recommended temperature of 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.