Description

5-Aminomethyluridine is a modified nucleoside building block of significant interest in advanced biochemical research and pharmaceutical development. Its unique structure, featuring an aminomethyl group at the 5-position of the uracil ring, makes it a critical intermediate for synthesizing oligonucleotides and exploring novel RNA therapeutics. This compound is primarily utilized by research institutions and biotechnology companies focused on antisense technology, mRNA vaccine platforms, and the development of diagnostic probes.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA strands.
• Antisense & RNA Therapeutics: Used to introduce specific modifications that can enhance stability, binding affinity, or alter the pharmacokinetic properties of therapeutic oligonucleotides.
• Bioconjugation & Probe Development: The primary amine group serves as a handle for attaching fluorescent dyes, affinity tags (e.g., biotin), or other functional moieties for diagnostic and research applications.
• Structural Biology Studies: Incorporated into RNA to study structure-function relationships and the impact of specific modifications on RNA folding and protein interactions.
• mRNA Vaccine & Therapeutic Research: Investigated for its potential to modify mRNA to improve translational efficiency or reduce immunogenicity.
• Chemical Biology Tool: Serves as a versatile scaffold for creating chemical libraries to screen for novel biological activity.

Basic Information

Product Name	5-Aminomethyluridine
CAS No.	190448-73-8
Molecular Formula	C10H15N3O6
Molecular Weight	273.24 g/mol
Synonyms	5-(Aminomethyl)uridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(aminomethyl)pyrimidine-2,4(1H,3H)-dione; 5-Carbamidomethyluridine (common misnomer); 5-AMU; Uridine, 5-(aminomethyl)-; 5-NH2-CH2-Urd
EINECS	Contact for details

Quality Control

Our 5-Aminomethyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity and impurity profiling. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure the material meets the stringent requirements for pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.