Description

5-Pyrimidinecarbonyl Chloride, 1,4,5,6-Tetrahydro- (9Ci) is a versatile and highly reactive heterocyclic acid chloride building block used in advanced organic synthesis. Its value lies in enabling the efficient introduction of the 1,4,5,6-tetrahydro-5-pyrimidinecarbonyl moiety, a key structural motif in medicinal chemistry. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active compounds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling, cross-linking, or modifying biomolecules in probe development and biochemical studies.
• Material Science Research: Employed in the synthesis of specialized polymers, ligands for catalysis, and other functional organic materials requiring this specific heterocyclic scaffold.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride, 1,4,5,6-Tetrahydro- (9Ci)
CAS No.	189361-35-1
Molecular Formula	C5H7ClN2O
Molecular Weight	146.57 g/mol
Synonyms	1,4,5,6-Tetrahydro-5-pyrimidinecarbonyl chloride; Tetrahydro-5-pyrimidinecarbonyl chloride; 5-Pyrimidinecarbonyl chloride, tetrahydro-; 1,4,5,6-Tetrahydro-5-pyrimidine carboxylic acid chloride; 5-(Chlorocarbonyl)-1,4,5,6-tetrahydropyrimidine; 1,2,3,6-Tetrahydropyrimidine-5-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-Pyrimidinecarbonyl Chloride, 1,4,5,6-Tetrahydro- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.