Description

4-Difluoromethoxyphenyl Isothiocyanate is a specialized aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the reactive isothiocyanate (-N=C=S) group, which enables efficient conjugation and derivatization for creating novel molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially for targeted therapies.
• Agrochemical Research: Building block for developing new herbicides, fungicides, and plant growth regulators.
• Ligand Synthesis: Used to create specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Bioconjugation Chemistry: Enables the labeling and modification of proteins, peptides, and other biomolecules.
• Material Science: Monomer for synthesizing polymers and advanced materials with specific optical or electronic properties.
• Chemical Biology Probes: Facilitates the development of activity-based probes for enzyme studies and diagnostic applications.

Basic Information

Product Name	4-Difluoromethoxyphenyl Isothiocyanate
CAS No.	189281-92-3
Molecular Formula	C8H5F2NOS
Molecular Weight	201.19 g/mol
Synonyms	1-Isothiocyanato-4-(difluoromethoxy)benzene; p-(Difluoromethoxy)phenyl Isothiocyanate; 4-(Difluoromethoxy)phenyl Isothiocyanate; 1-(Difluoromethoxy)-4-isothiocyanatobenzene; DFMP-ITC; 189281-92-3
EINECS	Contact for details

Quality Control

Our 4-Difluoromethoxyphenyl Isothiocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.