Description

3'-Epi-5-Chloro-2'-Deoxyuridine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical research and development. This compound is valued for its role as a synthetic intermediate in the creation of novel antiviral and anticancer agents, where structural modifications are critical for activity and selectivity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide metabolism.
• Pro-drug Development: Serves as a building block for designing pro-drugs with improved bioavailability and targeted delivery.
• Antiviral Agent Research: Investigated for its potential activity against DNA viruses due to its halogenated pyrimidine structure.
• Molecular Biology Tool: Employed in the study of DNA replication and repair processes.
• Fine Chemical Synthesis: Used as a specialized starting material for custom synthesis and contract manufacturing in advanced chemistry.

Basic Information

Product Name	3'-Epi-5-Chloro-2'-Deoxyuridine
CAS No.	188559-94-6
Molecular Formula	C9H11ClN2O5
Molecular Weight	262.65 g/mol
Synonyms	5-Chloro-3'-epi-2'-deoxyuridine; 3'-epi-5-Chloro-2'-deoxyuridine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-chloropyrimidine-2,4(1H,3H)-dione; 5-Chloro-1-(2-deoxy-3-epi-β-D-erythro-pentofuranosyl)uracil; 3'-epi-5-CldU; 3'-epi-5-Cl-dUrd
EINECS	Contact for details

Quality Control

Our 3'-Epi-5-Chloro-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.