Description

3-(6-Chloro-5-Fluoropyrimidin-4-Yl)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol Hydrochloride is a high-purity, non-racemic chiral intermediate of significant commercial importance. This compound is a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly for antifungal agents. It is essential for pharmaceutical R&D laboratories and manufacturers engaged in the production of novel triazole-based therapeutics. The compound's structural complexity demands stringent quality control to ensure downstream efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent systemic antifungal drugs.
• Antifungal API Development: Serves as a core structural component for triazole-class antifungal agents targeting fungal CYP51.
• Organic Synthesis Research: Used in academic and industrial research to explore new chemical entities and structure-activity relationships.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable, GMP-compliant manufacturing routes for final APIs.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	3-(6-Chloro-5-Fluoropyrimidin-4-Yl)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol Hydrochloride
CAS No.	188416-20-8
Molecular Formula	C16H12ClF3N5O • HCl
Molecular Weight	426.66 g/mol (Free base: 389.75 g/mol)
Synonyms	(2R,3R)-3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride; Voriconazole Intermediate; UK-109496 Intermediate; (2R,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride (chloro-substituted analog); PF-00951966 Intermediate (related); Triazole Antifungal Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% e.e. (specify isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.