Description

5-[(2-Cyanoethoxy)Methyl]-2’-Deoxycytidine is a specialized nucleoside derivative, a key intermediate in the synthesis of modified oligonucleotides. This compound matters for its crucial role in the development of advanced therapeutic and diagnostic agents, enabling precise genetic and molecular engineering. It is primarily needed by research institutions and pharmaceutical companies engaged in antisense therapy, siRNA development, and diagnostic probe manufacturing.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified DNA strands.
• Antisense & siRNA Therapeutics: Used in the research and production of oligonucleotide-based drugs targeting specific mRNA sequences.
• Molecular Diagnostics: Serves as a building block for labeled probes used in PCR, sequencing, and microarray technologies.
• Bioconjugation & Labeling: The cyanoethoxy moiety provides a handle for further chemical modification and attachment of reporter molecules.
• Academic & Industrial Research: Fundamental reagent for studying nucleic acid chemistry, structure, and function.

Basic Information

Product Name	5-[(2-Cyanoethoxy)Methyl]-2’-Deoxycytidine
CAS No.	188411-05-4
Molecular Formula	C13H18N4O5
Molecular Weight	310.31 g/mol
Synonyms	5-CEM-dC; 5-[(2-Cyanoethoxy)methyl]-2'-deoxycytidine; 2'-Deoxy-5-[(2-cyanoethoxy)methyl]cytidine; 5-(2-Cyanoethoxymethyl)-2'-deoxycytidine; dC-CE; 5-Cyanoethoxymethyl-2'-deoxycytidine; N4-Benzoyl-5-[(2-cyanoethoxy)methyl]-2'-deoxycytidine (protected form); CE-dC
EINECS	Contact for details

Quality Control

Our 5-[(2-Cyanoethoxy)Methyl]-2’-Deoxycytidine is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant internal specifications and support our customers' needs for GMP starting material documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.