Description

7-Iodo-8-Aza-7-Deaza-2'-Deoxyadenosine is a modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block for the synthesis of oligonucleotides with enhanced properties, such as increased nuclease resistance and altered binding affinity. It is primarily utilized by researchers and manufacturers in the fields of antiviral drug discovery, diagnostic probe development, and antisense technology. The high purity and reliable supply of this specialty chemical are essential for ensuring the reproducibility and success of cutting-edge life science applications.

Application

• Antiviral Drug Discovery: Used as a modified nucleoside precursor in the synthesis of potential therapeutic agents targeting viral polymerases.
• Diagnostic Probe Synthesis: Incorporated into oligonucleotide probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays due to its halogenated base.
• Antisense Oligonucleotide (ASO) Development: Serves as a key monomer to introduce specific modifications that enhance stability and target affinity of ASOs.
• Structural Biology Studies: Employed to investigate nucleic acid structure, function, and protein-nucleic acid interactions.
• Synthesis of Nucleoside Libraries: Acts as a versatile intermediate for creating diverse nucleoside analog libraries for high-throughput screening.
• Research on DNA Damage and Repair: Used as a tool compound to study the biological effects and repair mechanisms of modified DNA bases.

Basic Information

Product Name	7-Iodo-8-Aza-7-Deaza-2'-Deoxyadenosine
CAS No.	187479-00-1
Molecular Formula	C11H12IN5O3
Molecular Weight	389.15 g/mol
Synonyms	7-Iodo-7-deaza-8-aza-2'-deoxyadenosine; 7-Iodo-8-aza-7-deaza-2'-deoxyadenosine; 7-Iodo-8-aza-2'-deoxy-7-deazaadenosine; 7-Iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 2-deoxy-β-D-erythro-pentofuranosyl-; 2'-Deoxy-7-iodo-8-aza-7-deazaadenosine; 7-Iodo-8-aza-7-deaza-dA; 7-I-8-N-7-CN-2'-dA
EINECS	Contact for details

Quality Control

Our 7-Iodo-8-Aza-7-Deaza-2'-Deoxyadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to a cGMP-compliant quality management system to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.