Description

Cyclohexanecarbonyl Chloride, 4-Methoxy-, cis- (9Ci) is a specialized organic intermediate featuring a stereochemically defined cis-configured cyclohexane ring substituted with a methoxy group and a reactive acid chloride moiety. This compound matters for its role as a key chiral building block in the synthesis of complex molecules, where its defined stereochemistry and reactive functional group enable precise chemical transformations. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing advanced materials and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the cis-4-methoxycyclohexane scaffold imparts specific biological activity.
• Liquid Crystal & Advanced Material Precursor: Serves as a starting material for synthesizing chiral dopants and other components used in liquid crystal displays (LCDs) and organic electronic materials.
• Asymmetric Catalyst Ligand Synthesis: Employed in the preparation of novel, chiral ligands for asymmetric catalysis, enhancing the efficiency and selectivity of chemical reactions.
• Fine Chemical & Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke, multi-step synthesis projects requiring high-purity, stereochemically defined intermediates.
• Academic & Industrial Research: A valuable tool in organic chemistry research for studying structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 4-Methoxy-, cis- (9Ci)
CAS No.	187276-38-6
Molecular Formula	C8H13ClO2
Molecular Weight	176.64 g/mol
Synonyms	cis-4-Methoxycyclohexanecarbonyl Chloride; (1r,4r)-4-Methoxycyclohexane-1-carbonyl Chloride; 4-Methoxycyclohexanecarboxylic Acid Chloride, cis-; 4-Methoxycyclohexanecarbonyl Chloride (cis-); trans-4-Methoxycyclohexanecarbonyl Chloride (related isomer); 4-Methoxycyclohexanoyl Chloride; p-Methoxycyclohexanecarbonyl Chloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 4-Methoxy-, cis- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC and GC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support cGMP-compliant production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% cis-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.