Description

Diflomotecan is a synthetic camptothecin derivative and a potent topoisomerase I inhibitor. This compound is of significant interest in pharmaceutical research and development due to its mechanism of action, which targets DNA replication in rapidly dividing cells. It is primarily utilized by researchers and manufacturers in the oncology and life sciences sectors for the development of novel chemotherapeutic agents and as a critical reference standard in analytical studies.

Application

• Pharmaceutical R&D: Serves as a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of novel anticancer therapies.
• Oncology Research: Used in biochemical and cellular assays to study topoisomerase I inhibition, DNA damage, and apoptosis mechanisms.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate antitumor efficacy, pharmacokinetics, and toxicity profiles.
• Analytical Chemistry: Functions as a high-purity certified reference material (CRM) for method development, validation, and quality control in HPLC, LC-MS, and NMR analyses.
• Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex camptothecin analogs and conjugates.

Basic Information

Product Name	Diflomotecan
CAS No.	186668-70-2
Molecular Formula	C₂₄H₂₃F₂N₃O₅
Molecular Weight	471.45 g/mol
Synonyms	BN80915; BN 80915; 7-[(4-Methylpiperazino)methyl]-10,11-(methylenedioxy)-20(S)-camptothecin difluorinated analog; (19S)-10,11-Methylenedioxy-20-oxo-7-[(4-methyl-1-piperazinyl)methyl]-19-(trifluoroacetyl)camptothecin
EINECS	Contact for details

Quality Control

Our Diflomotecan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications to ensure consistency and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.