Description

Zibotentan (Zd4054) is a potent and selective endothelin A (ETA) receptor antagonist. This compound is of significant interest in pharmaceutical research and development, particularly for its potential therapeutic applications in oncology. It is primarily sought after by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in the development of novel cancer treatments and the study of endothelin receptor pathways.

Application

• Oncology Research: Primary application in preclinical and clinical research for investigating its efficacy against various cancers, most notably prostate cancer.
• Mechanistic Studies: Used as a selective pharmacological tool to study the role of endothelin A receptors in cell proliferation, angiogenesis, and bone metastasis.
• Drug Discovery & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of new endothelin receptor-targeted therapies.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to evaluate ETA receptor binding and functional activity.
• Academic Research: Utilized in university and institutional labs for fundamental research into cardiovascular and cancer biology pathways involving endothelin.

Basic Information

Product Name	Zibotentan (Zd4054)
CAS No.	186497-07-4
Molecular Formula	C19H16N4O4S
Molecular Weight	396.42 g/mol
Synonyms	ZD-4054; ZD4054; N-(3-Methoxy-5-methylpyrazin-2-yl)-2-(4-{[1,3,4-oxadiazol-2-yl)thio]methyl}-3-fluorophenyl)pyridine-3-sulfonamide; Zibotentan free base
EINECS	Contact for details

Quality Control

Our Zibotentan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with research-grade standards and support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic nature, the container should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.