Description

4-(1,2,2-Trifluorovinyl)Benzenesulfonyl Fluoride is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the trifluorovinyl and sulfonyl fluoride groups, enabling its use as a key precursor for the introduction of fluorinated motifs and as a versatile handle for click chemistry and SuFEx (Sulfur(VI) Fluoride Exchange) reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel, high-value fluorinated compounds.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly those requiring fluorinated aromatic systems to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental persistence.
• SuFEx Click Chemistry: Serves as an excellent electrophilic coupling partner in Sulfur(VI) Fluoride Exchange reactions, enabling the rapid and reliable construction of sulfonate ester and sulfonamide linkages for polymer science and bioconjugation.
• Fluorinated Polymer & Material Science: A key monomer or modifier for developing specialty polymers with enhanced properties such as chemical resistance, thermal stability, and low surface energy for coatings and membranes.
• Liquid Crystal & Electronic Materials: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) to improve performance characteristics.
• Radiotracer & Diagnostic Agent Precursor: The sulfonyl fluoride group provides a site for labeling with fluorine-18 (18F) or other isotopes for Positron Emission Tomography (PET) imaging probes.

Basic Information

Product Name	4-(1,2,2-Trifluorovinyl)Benzenesulfonyl Fluoride
CAS No.	185848-06-0
Molecular Formula	C8H4F4O2S
Molecular Weight	240.18 g/mol
Synonyms	p-(1,2,2-Trifluorovinyl)benzenesulfonyl fluoride; 4-(Trifluorovinyl)benzenesulfonyl fluoride; 1-(1,2,2-Trifluorovinyl)-4-fluorosulfonylbenzene; Benzenesulfonyl fluoride, 4-(1,2,2-trifluorovinyl)-; 4-(Perfluorovinyl)benzenesulfonyl fluoride (common name); 4-Vinyl-α,β,β-trifluorobenzenesulfonyl fluoride; TFVBSF (abbreviation); 185848-06-0 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-(1,2,2-Trifluorovinyl)Benzenesulfonyl Fluoride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, assay, and impurity profile. We support our clients' regulatory needs and ensure our products meet the stringent requirements for advanced synthetic chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.