Description

7-Ethyl-10-(4-Amino-1-Piperidino)Carbonyloxycamptothecin is a synthetic derivative of the potent topoisomerase I inhibitor, camptothecin, designed for enhanced solubility and targeted therapeutic efficacy. This compound is a critical pharmaceutical intermediate in the development of advanced oncology drugs, particularly for the synthesis of irinotecan and other related chemotherapeutic agents. It is essential for research institutions and pharmaceutical manufacturers engaged in anticancer drug discovery, formulation, and production.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Primary use in the synthesis of the chemotherapeutic drug irinotecan hydrochloride (CPT-11).
• Oncology Research: Serves as a key precursor in the development and study of novel camptothecin analogs and prodrugs.
• Preclinical & Clinical Development: Used in formulation studies for injectable and other dosage forms targeting solid tumors.
• Biochemical Research: Employed as a tool compound to investigate topoisomerase I inhibition mechanisms and cellular apoptosis.
• Process Chemistry & Scale-Up: Critical for process development and optimization in GMP-compliant manufacturing environments.

Basic Information

Item	Detail
Product Name	7-Ethyl-10-(4-Amino-1-Piperidino)Carbonyloxycamptothecin
CAS No.	185304-42-1
Molecular Formula	C27H30N4O5
Molecular Weight	490.55 g/mol
Synonyms	SN-38 Precursor; 7-Ethyl-10-hydroxycamptothecin 10-(4-Aminopiperidine-1-carbonyl) ester; Irinotecan Intermediate; CPT-11 Intermediate; 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin; (S)-7-Ethyl-10-hydroxycamptothecin 10-(4-aminopiperidine-1-carboxylate); 10-O-[((4-Amino-1-piperidinyl)carbonyl]-7-ethylcamptothecin
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-(4-Amino-1-Piperidino)Carbonyloxycamptothecin is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents is provided with every shipment. We support development with GMP-grade material and documentation for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.