Description

Rp-8-Bromo-β-Phenyl-1,N2-Ethenoguanosine 3',5'-Cyclic Monophosphorothioate Sodium Salt Hydrate is a chemically modified nucleotide analog of significant interest in biochemical and pharmacological research. This compound is valued for its role as a potent and selective activator of cyclic nucleotide-gated (CNG) ion channels and as a non-hydrolyzable analog of cyclic GMP (cGMP). It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced studies of cellular signaling pathways, particularly those involving photoreception, olfaction, and neuronal function.

Application

• Biochemical Research: As a high-affinity, phosphorothioate-stabilized activator for studying cyclic nucleotide-gated (CNG) ion channels in vitro.
• Neuroscience & Signal Transduction: Investigation of cGMP-mediated signaling cascades in phototransduction (vision) and olfactory sensory neurons.
• Drug Discovery & Pharmacology: Serving as a critical tool compound for screening and validating novel therapeutics targeting CNG channels and related pathways.
• Enzyme Studies: Used as a substrate analog to study the specificity and inhibition of phosphodiesterases (PDEs) and other nucleotide-metabolizing enzymes.
• Cellular Physiology: Probing the role of cGMP in regulating cellular processes such as apoptosis, smooth muscle relaxation, and gene expression.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, or NMR for quality control and method development in research settings.

Basic Information

Product Name	Rp-8-Bromo-β-Phenyl-1,N2-Ethenoguanosine 3',5'-Cyclic Monophosphorothioate Sodium Salt Hydrate
CAS No.	185246-32-6
Molecular Formula	C₁₈H₁₅BrN₅O₆PS•Na•xH₂O
Molecular Weight	Approx. 602.27 (Anhydrous Free Acid)
Synonyms	Rp-8-Br-PET-cGMPS Sodium Salt; Rp-8-Bromo-β-phenyl-1,N²-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt; Rp-8-Bromo-PET-cGMPS; 8-Bromo-β-phenyl-1,N²-ethenoguanosine 3',5'-cyclic monophosphorothioate, Rp-isomer, sodium salt; cGMP analog, Rp-8-Br-PET; Cyclic GMP antagonist analog; CNG channel activator
EINECS	Contact for details

Quality Control

Our Rp-8-Bromo-β-Phenyl-1,N2-Ethenoguanosine 3',5'-Cyclic Monophosphorothioate Sodium Salt Hydrate is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and specifications can be tailored to meet specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep containers sealed under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Confirmed in functional assay (data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.