Description

(1S-Trans)-2-Fluorocyclopropanecarbonyl Chloride is a high-purity, chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity conferred by the strained cyclopropane ring and the fluorine atom, enabling the precise construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and other bioactive molecules.
• Agrochemical Research: Used in the development of novel herbicides and pesticides where the fluorocyclopropane moiety can enhance metabolic stability and bioavailability.
• Material Science: Serves as a precursor for specialty polymers and advanced materials with tailored properties.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the chiral trans-fluorocyclopropane unit into target molecules.
• Fluorine Chemistry: A valuable reagent for studying structure-activity relationships (SAR) by incorporating fluorine atoms into lead compounds.
• Cross-Coupling Reactions: The acid chloride functionality makes it a suitable substrate for amidation and esterification reactions to create diverse compound libraries.

Basic Information

Product Name	(1S-Trans)-2-Fluorocyclopropanecarbonyl Chloride
CAS No.	185225-82-5
Molecular Formula	C4H4ClFO
Molecular Weight	122.52 g/mol
Synonyms	(1S,2S)-2-Fluorocyclopropanecarbonyl chloride; (1S-trans)-2-Fluorocyclopropanecarbonyl chloride; trans-(1S)-2-Fluorocyclopropanecarbonyl chloride; (1S,2S)-2-Fluorocyclopropanecarboxylic acid chloride; 2-Fluorocyclopropanecarboxylic acid chloride, (1S-trans)-; (1S,2S)-rel-2-Fluorocyclopropanecarbonyl Chloride
EINECS	Contact for details

Quality Control

Every batch of (1S-Trans)-2-Fluorocyclopropanecarbonyl Chloride is produced and tested under strict quality management protocols to ensure consistent purity and enantiomeric excess. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, it should be kept under an inert atmosphere (e.g., nitrogen or argon) and separated from bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.