Description

4-Pyrimidinecarbonyl Chloride (9Ci) is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its core value lies in its role as a versatile acylating and coupling agent, enabling the efficient construction of complex heterocyclic frameworks. This compound is critically needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of pyrimidine-based drug candidates, including kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that incorporate the pyrimidine moiety.
• Material Science Research: Serves as a precursor for creating functional polymers, ligands for metal-organic frameworks (MOFs), and other specialty materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, activity-based protein profiling (ABPP) reagents, and bioconjugation linkers.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Pyrimidinecarbonyl Chloride (9Ci)
CAS No.	184951-32-4
Molecular Formula	C5H3ClN2O
Molecular Weight	142.54 g/mol
Synonyms	Pyrimidine-4-carbonyl chloride; 4-Pyrimidinecarbonyl chloride; 4-Carboxypyrimidine chloride; Isonicotinoyl chloride, pyrimidine analog; Pyrimidine-4-carboxylic acid chloride; 4-Chlorocarbonylpyrimidine; 4-Pyrimidinecarboxylic acid chloride; 184951-32-4
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinecarbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support compliance with cGMP and ICH guidelines where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.