Description

[6,7-Bis(2-Chloroethoxy)-Quinazolin-4-Yl]-(3-Ethynylphenyl)Amine Hydrochloride is a high-purity, synthetically derived small molecule compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key chemical intermediate or reference standard for the synthesis of targeted therapeutic agents, particularly kinase inhibitors. This product is essential for research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in oncology, immunology, and other life science fields requiring precise molecular building blocks.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel, targeted small-molecule drugs, particularly kinase inhibitors.
• Oncology Research: Used in the development and study of potential anti-cancer compounds targeting specific cellular pathways.
• Biochemical Tool Compound: Serves as a reference standard or a precursor for creating biochemical probes to study enzyme function and signal transduction.
• API Development: Employed in the research phase of Active Pharmaceutical Ingredient (API) process development and optimization.
• Preclinical Studies: Utilized in *in vitro* and *in vivo* studies to establish proof-of-concept for new therapeutic candidates.
• Custom Synthesis Starting Material: Supplied to fine chemical manufacturers for the custom synthesis of more complex, client-specific molecules.

Basic Information

Product Name	[6,7-Bis(2-Chloroethoxy)-Quinazolin-4-Yl]-(3-Ethynylphenyl)Amine Hydrochloride
CAS No.	183320-00-5
Molecular Formula	C20H17Cl3N4O2
Molecular Weight	451.73 g/mol
Synonyms	N-(3-Ethynylphenyl)-6,7-bis(2-chloroethoxy)-4-quinazolinamine hydrochloride; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-chloroethoxy)quinazoline hydrochloride; BIBX 1382 dihydrochloride (common research alias); EGFR Inhibitor (functional descriptor); Tyrosine Kinase Inhibitor Intermediate; 183320-00-5 (CAS registry); 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-chloroethoxy)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our [6,7-Bis(2-Chloroethoxy)-Quinazolin-4-Yl]-(3-Ethynylphenyl)Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.