Description

2'-Tfa-Nh-Da CAS NO 182626-53-5 is a specialized chemical intermediate, primarily recognized as a protected nucleoside derivative used in oligonucleotide synthesis. Its value lies in enabling the precise construction of DNA/RNA sequences for research and therapeutic development. This product is essential for biotechnology and pharmaceutical companies engaged in antisense therapy, diagnostic probe development, and academic research requiring high-purity synthetic building blocks.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for automated DNA/RNA synthesizers.
• Antisense Oligonucleotide (ASO) Manufacturing: Used in the production of therapeutic oligonucleotides for targeting specific mRNA sequences.
• Research & Diagnostic Probe Development: Serves as a critical building block for creating labeled probes used in PCR, FISH, and microarray technologies.
• siRNA and miRNA Synthesis: Integral to the manufacture of small interfering RNA and microRNA for gene silencing applications.
• Pharmaceutical Intermediate: Employed in the research and development stages of novel nucleic acid-based drugs.
• Academic & Institutional Research: Used in laboratories studying nucleic acid chemistry, structure, and function.

Basic Information

Product Name	2'-Tfa-Nh-Da
CAS No.	182626-53-5
Molecular Formula	C₁₈H₂₁N₅O₆
Molecular Weight	403.39 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-(trifluoroacetyl)-N6-benzoyl-2'-deoxyadenosine; 2'-O-Trifluoroacetyl-N6-benzoyl-5'-O-DMT-2'-deoxyadenosine; DMT-dA(Bz)-2'-TFA Amidite precursor; 2'-Deoxy-2'-(trifluoroacetamido)adenosine derivative; N6-Benzoyl-2'-O-trifluoroacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine; 2'-TFA Protected deoxyadenosine; 2'-TFA-N-Bz-dA(DMT)
EINECS	Contact for details

Quality Control

Every batch of 2'-Tfa-Nh-Da is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the exacting standards required for oligonucleotide synthesis. We provide a detailed Certificate of Analysis (COA) with each shipment, reporting key parameters such as purity (by HPLC), identity (by NMR and MS), and moisture content. Our quality commitment supports applications in GMP-grade therapeutic development and cGMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.