Description

4H-Thieno[3,2-B]Pyrrole-5-Carbonyl Chloride is a high-value, heterocyclic acid chloride building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its unique fused thienopyrrole structure.
• Material Science: Serves as a monomer or precursor for constructing advanced organic electronic materials, such as semiconductors or conductive polymers.
• Peptide Mimetics & Bioconjugation: The reactive carbonyl chloride group enables efficient amide bond formation for creating peptide analogs or bioconjugates.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying biological processes and target identification.
• Scale-Up Process Development: Supplied for optimization and scaling of synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	4H-Thieno[3,2-B]Pyrrole-5-Carbonyl Chloride
CAS No.	182553-05-5
Molecular Formula	C7H4ClNOS
Molecular Weight	185.63 g/mol
Synonyms	4H-Thieno[3,2-b]pyrrole-5-carbonyl chloride; Thieno[3,2-b]pyrrole-5-carbonyl chloride; 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid chloride; 182553-05-5; 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, chloride; Thienopyrrole-5-carbonyl chloride; 5-(Chlorocarbonyl)-4H-thieno[3,2-b]pyrrole
EINECS	Contact for details

Quality Control

Every batch of 4H-Thieno[3,2-B]Pyrrole-5-Carbonyl Chloride is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with cGMP principles where applicable, supporting your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.