Description

2'-Deoxy-2'-Fluoro-N4-Benzoyl-5-Methylcytidine is a high-purity, chemically modified nucleoside derivative of significant importance in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and building block for the production of oligonucleotide therapeutics, including antisense drugs and siRNA. It is primarily required by pharmaceutical companies, biotechnology research institutions, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel antiviral and anticancer therapies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of fluorinated oligonucleotides, enhancing their stability and binding affinity.
• Antisense Drug Development: Used in the research and manufacturing of antisense oligonucleotides (ASOs) targeting specific mRNA sequences for therapeutic intervention.
• siRNA and RNAi Therapeutics: Incorporated into small interfering RNA (siRNA) strands to improve nuclease resistance and pharmacokinetic properties.
• Antiviral Research: Serves as a modified nucleoside analog in the investigation of novel antiviral agents, particularly against RNA viruses.
• Medicinal Chemistry: A valuable building block for medicinal chemists exploring structure-activity relationships (SAR) in nucleoside-based drug candidates.
• Diagnostic Probe Development: Utilized in the creation of labeled probes for genetic testing and molecular diagnostics due to its modified structure.

Basic Information

Product Name	2'-Deoxy-2'-Fluoro-N4-Benzoyl-5-Methylcytidine
CAS No.	182495-81-4
Molecular Formula	C17H18FN3O5
Molecular Weight	363.34 g/mol
Synonyms	5-Methyl-2'-deoxy-2'-fluorocytidine N4-benzoate; 2'-Fluoro-5-methyl-N4-benzoyl-2'-deoxycytidine; 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-ium-2-olate N4-benzoate; 2'-F-5-Me-C(Bz); 5-Methyl-2'-fluoro-2'-deoxycytidine, N4-benzoyl-; N4-Benzoyl-2'-deoxy-2'-fluoro-5-methylcytidine; 2'-Deoxy-2'-fluoro-5-methylcytidine N4-benzoate
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro-N4-Benzoyl-5-Methylcytidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.